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Literature summary for 3.1.1.118 extracted from

  • Inloes, J.M.; Jing, H.; Cravatt, B.F.
    The spastic paraplegia-associated phospholipase DDHD1 is a primary brain phosphatidylinositol lipase (2018), Biochemistry, 57, 5759-5767 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.118

Organism

Organism UniProt Comment Textmining
Mus musculus Q80YA3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-oleyl-2-arachidonoyl-phosphatidylinositol + H2O
-
 Mus musculus 2-arachidonoyl-lysophosphatidylinositol + oleate
-
 ?
phosphatidylinositol + H2O
-
 Mus musculus lysophosphatidylinositol + ?
-
 ?
phosphatidylserine + H2O
-
 Mus musculus lyso-phosphatidylserine + ?
-
 ?

Subunits

Subunits Comment Organism
? x * about 100000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
DDHD1
-
 Mus musculus
phosphatidic acid-preferring phospholipase A1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction deleterious mutations in the enzyme cause the SPG28 subtype of the neurological disease Hereditary Spastic Paraplegia which is characterized by axonal neuropathy and gait impairments. Enzyme inactivation causes a substantial decrease in polyunsaturated lysophosphatidylinositol lipids and an corresponding increase in phosphatidylinositol lipids Mus musculus
metabolism the enzyme regulates brain lysophospholipid and phosphatidylinositol content in vivo Mus musculus